Whether monolayers will replace silicon in semiconductors is a hard question to answer and depends on the practicality of creating large-scale monolayer structures. Researchers have easily created monolayer semiconductors, created basic devices, and measured their characteristics, but there is a big difference between creating one transistor and one billion.

There is no doubt that monolayers have many advantages; they form very different contacts with other materials compared to standard crystalline structures. They have unique properties and are often free from imperfections and defects.

However, silicon as a semiconductor is an established technology. While monolayers may allow for the creation of more advanced future devices, silicon will still be the de facto technology found in everyday silicon that does not need to operate at excellent efficiency, high speed, or at nanometer scales.